CNOT9 and GIGYF2

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, pull down)

		CNOT9	GIGYF2
Description		CCR4-NOT transcription complex subunit 9	GRB10 interacting GYF protein 2
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GO Annotations	Cellular Component	P-body Nucleus Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex Protein-containing Complex	Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoplasmic Stress Granule Membrane Protein-containing Complex Perikaryon Proximal Dendrite
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Kinase Binding Protein Domain Specific Binding Nuclear Receptor Coactivator Activity Protein Homodimerization Activity	RNA Binding Protein Binding Cadherin Binding Proline-rich Region Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Sex Differentiation Negative Regulation Of Translation Cytokine-mediated Signaling Pathway Gene Silencing By RNA Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated	Posttranscriptional Gene Silencing Negative Regulation Of Translation Insulin-like Growth Factor Receptor Signaling Pathway MRNA Destabilization
Pathways		Deadenylation of mRNA Activation of anterior HOX genes in hindbrain development during early embryogenesis TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases			Parkinson's disease (PD)
GWAS			Anxiety and stress-related disorders ( 31116379) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 32469254 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Schizophrenia ( 25056061 29483656 23974872)
Interacting Genes		10 interacting genes: AKT1 EGFR GADD45A GADD45B GADD45G GIGYF1 GIGYF2 GRB10 MESD MYB	8 interacting genes: APC CNOT9 GRB10 GRB14 GRB7 RBM12 SNRPB WBP11
Entrez ID		9125	26058
HPRD ID		08828	11639
Ensembl ID		ENSG00000144580	ENSG00000204120
Uniprot IDs		D5MQE1 Q92600	Q6Y7W6
PDB IDs		2FV2 4CRU 4CRV 4CT6 4CT7 5LSW 5ONA 5ONB 6HOM 6HON	5NVL 5NVM
Enriched GO Terms of Interacting Partners?
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