PKMYT1 and CLDN8

Data Source:
BioGRID (two hybrid)

		PKMYT1	CLDN8
Description		protein kinase, membrane associated tyrosine/threonine 1	claudin 8
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Endoplasmic Reticulum Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Regulation Of Mitotic Nuclear Division Negative Regulation Of Phosphatase Activity Meiotic Cell Cycle	Cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly
Pathways		Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint	Tight junction interactions
Drugs		Fostamatinib
Diseases
GWAS		Metabolic syndrome ( 20694148)	Response to statin therapy ( 20339536)
Interacting Genes		24 interacting genes: ABHD16A BCL2 CCNB1 CD3E CD79A CDK1 CLDN8 ELOVL4 FATE1 LIME1 LRRC25 MAPK10 MAPK8 MFSD14B MFSD5 PIN1 PLK1 RETREG3 SLC10A1 SLC30A8 STEAP3 TMEM101 TMEM229B TMX2	12 interacting genes: ADAM32 ARL13B CLEC17A ERGIC3 KASH5 OPRM1 PKMYT1 SMIM3 SYNE4 TJP1 TMEM80 TRARG1
Entrez ID		9088	9073
HPRD ID		03920	10835
Ensembl ID		ENSG00000127564	ENSG00000156284
Uniprot IDs		Q0IJ49 Q99640	A0A0K0K1I9 P56748
PDB IDs		3P1A 5VCV 5VCW 5VCX 5VCY 5VCZ 5VD0 5VD1 5VD3
Enriched GO Terms of Interacting Partners?
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