ASH2L and MYOM3

Data Source:
BioGRID (two hybrid)

		ASH2L	MYOM3
Description		ASH2 like, histone lysine methyltransferase complex subunit	myomesin 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex	M Band
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding	Protein Homodimerization Activity Actin Filament Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Hemopoiesis Response To Estrogen Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly	Muscle Contraction
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656)	Bipolar disorder with mood-incongruent psychosis ( 23092984) Chronotype ( 30696823) Vigorous physical activity ( 29899525)
Interacting Genes		37 interacting genes: ACTC1 ACTN2 ANKRD1 BARD1 BRCA1 CCNC CEP76 CHD8 COPS6 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 MESD MKRN1 MYBPC1 MYOM3 PPP1CC PRMT1 RBBP5 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 TTN UNC119 WDR5 WWP1 ZSCAN1	6 interacting genes: AMOT ASH2L FEM1A GORASP2 NMI RND1
Entrez ID		9070	127294
HPRD ID		05309	08200
Ensembl ID		ENSG00000129691	ENSG00000142661
Uniprot IDs		B4DPT1 F5H8F7 Q9UBL3	Q5VTT5
PDB IDs		3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ 6PWV 7BRE
Enriched GO Terms of Interacting Partners?
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