BMF and NNMT

Data Source:
BioGRID (two hybrid)

		BMF	NNMT
Description		Bcl2 modifying factor	nicotinamide N-methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Mitochondrial Outer Membrane Cytosol Plasma Membrane Myosin Complex	Cytosol
	Molecular Function	Protein Binding	Nicotinamide N-methyltransferase Activity N-methyltransferase Activity Pyridine N-methyltransferase Activity
	Biological Process	Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV Positive Regulation Of Apoptotic Process Anoikis Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Response To Organonitrogen Compound Animal Organ Regeneration Methylation NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Response To Drug
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria	Methylation Nicotinamide salvaging Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs			Niacin
Diseases
GWAS		B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 28165464 26956414 24292274) Dehydroepiandrosterone sulphate levels ( 21533175) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Ewing sarcoma ( 22327514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Triglyceride levels ( 32203549)	Asthma ( 29273806) Diisocyanate-induced asthma ( 25918132) Volumetric brain MRI ( 17903297)
Interacting Genes		26 interacting genes: AQP1 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BCL2L2-PABPN1 CTAG1A CTAG1B CXCL9 DYNLL1 DYNLL2 GPSM3 LCN2 MAPK8 MCL1 MGAT5B MYO5A NNMT RECK REL SEC14L4 SHC3 TCF12 TFIP11 TRIM54	3 interacting genes: APP ATF6 BMF
Entrez ID		90427	4837
HPRD ID		05881	02478
Ensembl ID		ENSG00000104081	ENSG00000166741
Uniprot IDs		Q96LC9	P40261 Q6FH49
PDB IDs			2IIP 3ROD 5YJF 6B1A 6CHH 6ORR 6PVE 6PVS
Enriched GO Terms of Interacting Partners?
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