BMF and BCL2L10

Data Source:
BioGRID (two hybrid)

		BMF	BCL2L10
Description		Bcl2 modifying factor	BCL2 like 10
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Mitochondrial Outer Membrane Cytosol Plasma Membrane Myosin Complex	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Membrane Integral Component Of Membrane Nuclear Membrane Mitochondria-associated Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Caspase Binding
	Biological Process	Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV Positive Regulation Of Apoptotic Process Anoikis Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Spermatogenesis Female Gamete Generation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria
Drugs
Diseases
GWAS		B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 28165464 26956414 24292274) Dehydroepiandrosterone sulphate levels ( 21533175) Endometrial cancer ( 30093612 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Ewing sarcoma ( 22327514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		26 interacting genes: AQP1 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BCL2L2-PABPN1 CTAG1A CTAG1B CXCL9 DYNLL1 DYNLL2 GPSM3 LCN2 MAPK8 MCL1 MGAT5B MYO5A NNMT RECK REL SEC14L4 SHC3 TCF12 TFIP11 TRIM54	15 interacting genes: APAF1 BAD BAK1 BAX BCL2 BCL2L1 BCL2L11 BECN1 BIK BMF CASP8 MGST2 NR4A1 SAMD4B TMEM200A
Entrez ID		90427	10017
HPRD ID		05881	06071
Ensembl ID		ENSG00000104081	ENSG00000137875
Uniprot IDs		Q96LC9	H0YMD5 Q9HD36
PDB IDs			4B4S
Enriched GO Terms of Interacting Partners?
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