SENP8 and USP21

Data Source:
BioGRID (enzymatic study)

		SENP8	USP21
Description		SUMO peptidase family member, NEDD8 specific	ubiquitin specific peptidase 21
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GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding NEDD8-specific Protease Activity	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding
	Biological Process	Protein Deubiquitination Post-translational Protein Modification	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Neuron Projection Development Positive Regulation Of Transcription, DNA-templated
Pathways		UCH proteinases Neddylation	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS		Metabolite levels (HVA/MHPG ratio) ( 23319000)
Interacting Genes		15 interacting genes: CHN2 COPS2 CUL1 CUL2 CUL4A GPS1 HSPA4 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28	59 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXM1 H2AC18 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350
Entrez ID		123228	27005
HPRD ID		09784	05291
Ensembl ID		ENSG00000166192	ENSG00000143258
Uniprot IDs		A8K8D3 Q96LD8	Q9UK80
PDB IDs		1XT9 2BKQ 2BKR	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?
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