UBA3 and NAE1

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid, in vivo)

		UBA3	NAE1
Description		ubiquitin like modifier activating enzyme 3	NEDD8 activating enzyme E1 subunit 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Protein-containing Complex	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Binding ATP Binding Nuclear Receptor Binding NEDD8 Activating Enzyme Activity NEDD8 Transferase Activity Identical Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity
	Biological Process	Cellular Protein Modification Process Proteolysis Endomitotic Cell Cycle Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle	Signal Transduction Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Mitotic DNA Replication Checkpoint Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation Neuron Apoptotic Process
Pathways		Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Neddylation
Drugs			ATP
Diseases
GWAS		Meat-related diet ( 32066663)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		12 interacting genes: CHD3 CPNE2 DUSP23 IMPA2 KDM1A NAE1 NEDD8 TRIM55 TRIM63 UBE2D2 UBE2F UBE2M	10 interacting genes: ALG8 APP GARS1 NEDD8 SREBF2 TP53BP2 TRIP12 UBA3 UBE2F UBQLN4
Entrez ID		9039	8883
HPRD ID		04413	04545
Ensembl ID		ENSG00000144744	ENSG00000159593
Uniprot IDs		Q8TBC4	Q13564
PDB IDs		1R4M 1R4N 1TT5 1Y8X 1YOV 2LQ7 2NVU 3DBH 3DBL 3DBR 3FN1 3GZN 5JJM	1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
Enriched GO Terms of Interacting Partners?
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