NAE1 and UBE2F

Data Source:
BioGRID (enzymatic study)

		NAE1	UBE2F
Description		NEDD8 activating enzyme E1 subunit 1	ubiquitin conjugating enzyme E2 F (putative)
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Nucleus Cytosol
	Molecular Function	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity	Protein Binding ATP Binding NEDD8 Transferase Activity NEDD8 Conjugating Enzyme Activity
	Biological Process	Signal Transduction Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Mitotic DNA Replication Checkpoint Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation Neuron Apoptotic Process	Protein Phosphopantetheinylation Post-translational Protein Modification Protein Neddylation
Pathways		Neddylation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		ATP
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	Lean body mass ( 28552196)
Interacting Genes		10 interacting genes: ALG8 APP GARS1 NEDD8 SREBF2 TP53BP2 TRIP12 UBA3 UBE2F UBQLN4	12 interacting genes: CUL1 CUL5 DCUN1D1 DCUN1D2 DCUN1D5 LCN2 NAE1 PAX6 RC3H1 RNF34 RNF7 UBA3
Entrez ID		8883	140739
HPRD ID		04545	14812
Ensembl ID		ENSG00000159593	ENSG00000184182
Uniprot IDs		Q13564	Q969M7
PDB IDs		1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN	2EDI 3FN1 4GBA
Enriched GO Terms of Interacting Partners?
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