CCNH and MTMR7

Data Source:
BioGRID (two hybrid)

		CCNH	MTMR7
Description		cyclin H	myotubularin related protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex CAK-ERCC2 Complex Transcription Factor TFIIK Complex	Cytoplasm Cytosol Endomembrane System Membrane
	Molecular Function	Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	Phosphatidylinositol-3-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Stabilization Phosphorylation Of RNA Polymerase II C-terminal Domain	Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Peptidyl-tyrosine Dephosphorylation Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs	Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of IP2, IP, and Ins in the cytosol
Drugs
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Blood protein levels ( 29875488) Diastolic blood pressure ( 27841878) Initial pursuit acceleration ( 29064472) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Prostate cancer aggressiveness ( 25939597) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Creutzfeldt-Jakob disease (variant) ( 22137330) Schizophrenia ( 28991256)
Interacting Genes		48 interacting genes: AR BLZF1 CALCOCO2 CCDC170 CCDC33 CCNC CCT4 CDK2 CDK20 CDK3 CDK6 CDK7 CDK8 CSNK2B CTBP2 DUSP12 ERCC3 ESR1 FUBP1 GANAB GOLGA2 GRIPAP1 GTF2E2 GTF2H1 KLC3 MCM7 MCRS1 MTA1 MTMR7 NDC80 NEDD4 PICK1 POLR2A POLR2B PPFIA1 PSMA1 RARB RHOH SFN SORBS3 SSX2IP SUPT5H TCF4 TP53 TRIM8 TRIML2 ZNF655 ZNRD2	2 interacting genes: CCNH MTMR9
Entrez ID		902	9108
HPRD ID		09059	16027
Ensembl ID		ENSG00000134480	ENSG00000003987
Uniprot IDs		P51946	B7Z9Q7 B7ZAG8 Q9Y216
PDB IDs		1JKW 1KXU 6O9L 6XBZ 6XD3
Enriched GO Terms of Interacting Partners?
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