CCNH and GTF2E2

Data Source:
HPRD (in vitro)

		CCNH	GTF2E2
Description		cyclin H	general transcription factor IIE subunit 2
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GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex CAK-ERCC2 Complex Transcription Factor TFIIK Complex	Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIE Complex Cytosol Nuclear Speck
	Molecular Function	Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	DNA Binding RNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Assembly Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Stabilization Phosphorylation Of RNA Polymerase II C-terminal Domain	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Blood protein levels ( 29875488) Diastolic blood pressure ( 27841878) Initial pursuit acceleration ( 29064472) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Prostate cancer aggressiveness ( 25939597) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Cognitive performance ( 20125193) Mean corpuscular volume ( 32888494) Metabolite levels (X-11787) ( 23934736)
Interacting Genes		48 interacting genes: AR BLZF1 CALCOCO2 CCDC170 CCDC33 CCNC CCT4 CDK2 CDK20 CDK3 CDK6 CDK7 CDK8 CSNK2B CTBP2 DUSP12 ERCC3 ESR1 FUBP1 GANAB GOLGA2 GRIPAP1 GTF2E2 GTF2H1 KLC3 MCM7 MCRS1 MTA1 MTMR7 NDC80 NEDD4 PICK1 POLR2A POLR2B PPFIA1 PSMA1 RARB RHOH SFN SORBS3 SSX2IP SUPT5H TCF4 TP53 TRIM8 TRIML2 ZNF655 ZNRD2	26 interacting genes: APP ATF7IP CCNH CDK7 ERCC3 ERCC6 EXOC8 FOS GTF2A1 GTF2B GTF2E1 GTF2F1 GTF2F2 GTF2H1 JUN KAT5 KLF5 MCC MDM2 MNAT1 NUP62 PICK1 SND1 SUPT16H TBP XPA
Entrez ID		902	2961
HPRD ID		09059	01800
Ensembl ID		ENSG00000134480	ENSG00000197265
Uniprot IDs		P51946	P29084
PDB IDs		1JKW 1KXU 6O9L 6XBZ 6XD3	1D8J 1D8K 5GPY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L
Enriched GO Terms of Interacting Partners?
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