ACVR1 and INHBA

Data Source:
HPRD (in vivo)

		ACVR1	INHBA
Description		activin A receptor type 1	inhibin subunit beta A
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Apical Part Of Cell Activin Receptor Complex BMP Receptor Complex	Extracellular Region Extracellular Space Activin A Complex Inhibin A Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Peptide Hormone Binding Protein Homodimerization Activity Cadherin Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding Protein Tyrosine Kinase Binding	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Peptide Hormone Binding Inhibin Binding Identical Protein Binding Protein-containing Complex Binding Type II Activin Receptor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Angiogenesis Branching Involved In Blood Vessel Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Mesoderm Formation Neural Crest Cell Migration Acute Inflammatory Response Embryonic Heart Tube Morphogenesis Outflow Tract Septum Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion Morphogenesis Endocardial Cushion Fusion Atrial Septum Primum Morphogenesis Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Germ Cell Development Determination Of Left/right Symmetry Heart Development Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Ossification Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Smooth Muscle Cell Differentiation Pharyngeal System Development Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Cardiac Muscle Cell Fate Commitment BMP Signaling Pathway Involved In Heart Development Endocardial Cushion Cell Fate Commitment Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Ovarian Follicle Development Hair Follicle Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Defense Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Wounding Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Striatal Medium Spiny Neuron Differentiation Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Interferon-gamma Production Activin Receptor Signaling Pathway Endodermal Cell Differentiation Negative Regulation Of Phosphorylation Odontogenesis Response To Drug Hemoglobin Biosynthetic Process Progesterone Secretion Negative Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Mesodermal Cell Differentiation Roof Of Mouth Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Eyelid Development In Camera-type Eye Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol GABAergic Neuron Differentiation Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Signaling by Activin Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin
Drugs		ATP Dorsomorphin Fostamatinib
Diseases		Fibrodysplasia ossificans progressiva (FOP)
GWAS		Severe gingival inflammation ( 28459102)	Asthma ( 29273806) Cortisol levels (saliva) ( 28843169) Menarche (age at onset) ( 27182965 21102462 25231870) Parent of origin effect on language impairment (paternal) ( 24571439) Pit-and-Fissure caries ( 23470693)
Interacting Genes		70 interacting genes: AP2B1 BAMBI BMP2 BMP6 BMP7 BMPR1A BMPR2 CDK14 CHN1 CREBBP DCAF6 DUSP13 ENG FANCL FBXO30 FBXO7 FCHO1 FGD6 FKBP4 FNTA GDF2 GDF5 IGSF1 IKBKB INHBA INHBB INHBC KLHL35 NEK8 NKIRAS1 NRAS NUAK2 OTUB1 PAK1 PLEK PLEKHB1 PLEKHJ1 RAB17 RAB25 RAB33B RAB3B RAB6B RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 RXRA SMAD1 SMAD5 SMAD9 SOCS6 STIP1 STX8 TDGF1 TGFBR1 TGFBR2 THRB TTC17 TTC27 UBA52 UBE2E3 UBXN1 USP39 VDR VEPH1 WDR61	13 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B CHRDL2 ENG FST FSTL3 IGFBP7 INHA INHBB INHBC TGFBR3
Entrez ID		90	3624
HPRD ID		00021	00929
Ensembl ID		ENSG00000115170	ENSG00000122641
Uniprot IDs		D3DPA4 Q04771	A4D1W7 P08476
PDB IDs		3H9R 3MTF 3OOM 3Q4U 4BGG 4C02 4DYM 5OXG 5OY6 6ACR 6EIX 6GI6 6GIN 6GIP 6I1S 6JUX 6SRH 6SZM 6T6D 6T8N 6TN8 6Z36 6ZGC 7A21	1NYS 1NYU 1S4Y 2ARP 2ARV 2B0U 2P6A 3B4V 4MID 5HLY 5HLZ
Enriched GO Terms of Interacting Partners?
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