LHX4 and SNRNP25

Data Source:
BioGRID (two hybrid)

		LHX4	SNRNP25
Description		LIM homeobox 4	small nuclear ribonucleoprotein U11/U12 subunit 25
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytosol Intercellular Bridge
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Placenta Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	MRNA Splicing, Via Spliceosome RNA Splicing
Pathways		Regulation of expression of SLITs and ROBOs	mRNA Splicing - Minor Pathway
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Refractive error ( 32231278)	Body mass index ( 26426971)
Interacting Genes		53 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB1 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 YY1 ZBTB2 ZNF354C ZNF76	17 interacting genes: BPIFA1 CPSF7 EFHC2 KRT31 LHX3 LHX4 LNX1 NKAPD1 OIP5 PFDN5 PICK1 REL TDRKH TEPSIN TRAF1 TRAF2 UBC
Entrez ID		89884	79622
HPRD ID		03686	12673
Ensembl ID		ENSG00000121454	ENSG00000161981
Uniprot IDs		A0A0S2Z5S4 Q969G2	Q4TT61 Q9BV90
PDB IDs		5HOD
Enriched GO Terms of Interacting Partners?
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