LHX4 and ARL2

Data Source:
BioGRID (two hybrid)

		LHX4	ARL2
Description		LIM homeobox 4	ADP ribosylation factor like GTPase 2
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GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Intermembrane Space Mitochondrial Matrix Golgi Apparatus Centrosome Cytosol Focal Adhesion Cilium Microtubule Cytoskeleton Lateral Plasma Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Placenta Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II	Tubulin Complex Assembly Centrosome Cycle Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Regulation Of Insulin Secretion Maintenance Of Protein Location In Nucleus Bicellular Tight Junction Assembly
Pathways		Regulation of expression of SLITs and ROBOs	Post-chaperonin tubulin folding pathway Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane RAS processing
Drugs			Tagraxofusp
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Refractive error ( 32231278)
Interacting Genes		53 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB1 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 YY1 ZBTB2 ZNF354C ZNF76	6 interacting genes: ARL2BP LHX4 PDE6D TBCD TBL1XR1 UNC119
Entrez ID		89884	402
HPRD ID		03686	11869
Ensembl ID		ENSG00000121454	ENSG00000213465
Uniprot IDs		A0A0S2Z5S4 Q969G2	P36404 Q53YD8
PDB IDs		5HOD	3DOE 3DOF
Enriched GO Terms of Interacting Partners?
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