GC and CDC73

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GC	CDC73
Description		GC vitamin D binding protein	cell division cycle 73
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Lysosomal Lumen Extracellular Exosome Blood Microparticle	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex
	Molecular Function	Actin Binding Vitamin D Binding Vitamin Transmembrane Transporter Activity Calcidiol Binding	RNA Polymerase II Complex Binding Protein Binding
	Biological Process	Transport Vitamin Transmembrane Transport Vitamin D Metabolic Process Vitamin Transport	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Population Proliferation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Beta-catenin-TCF Complex Assembly Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Vitamin D (calciferol) metabolism	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Vitamin D
Diseases			Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Blood protein levels ( 29875488) Granulocyte count ( 27863252) Lymphocyte counts ( 32888494) Metabolite levels ( 22916037) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Neutrophil count ( 32888494 27863252) Non-alcoholic fatty liver disease histology (other) ( 23213074) Platelet count ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum 25-Hydroxyvitamin D levels ( 29545823 29325163 31841498) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum vitamin D-binding protein levels ( 24740207) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 29343764 22673963 20418485 25208829) Vitamin D levels (dietary vitamin D intake interaction) ( 29343764) White blood cell count ( 32888494 27863252)	Chronotype ( 30696823) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)
Interacting Genes		12 interacting genes: ACTA1 ACTA2 ACTC1 C3 CCND3 CDC73 CUBN GRB2 LRIF1 LRP2 PIK3R3 SERF2	35 interacting genes: ALAS1 ANXA6 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 VPS37B WWC1
Entrez ID		2638	79577
HPRD ID		00749	09581
Ensembl ID		ENSG00000145321	ENSG00000134371
Uniprot IDs		P02774	Q6P1J9
PDB IDs		1J78 1J7E 1KW2 1KXP 1LOT 1MA9	5YDE 5YDF 6TED
Enriched GO Terms of Interacting Partners?
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