MTMR2 and ERBB4

Data Source:
BioGRID (two hybrid)

		MTMR2	ERBB4
Description		myotubularin related protein 2	erb-b2 receptor tyrosine kinase 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Vacuolar Membrane Cytosol Synaptic Vesicle Postsynaptic Density Membrane Axon Dendrite Early Endosome Membrane Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Synaptic Membrane	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Receptor Complex Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Identical Protein Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity	Transcription Regulatory Region Sequence-specific DNA Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Receptor Internalization Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Negative Regulation Of Myelination Myelin Assembly Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Endocytosis Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Neuron Development Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Maintenance Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Receptor Catabolic Process	MAPK Cascade Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Synapse Assembly Heart Development Lactation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Regulation Of Cell Migration Positive Regulation Of Kinase Activity ERBB2 Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Mitochondrial Fragmentation Involved In Apoptotic Process Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Autophosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Localization To Cell Surface Regulation Of Cell Motility Negative Regulation Of Neuron Migration
Pathways		Synthesis of PIPs at the ER membrane Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs			Afatinib Fostamatinib Brigatinib Zanubrutinib
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 32888494) Triglyceride levels x loop diuretics use interaction ( 31806883) Waist circumference adjusted for body mass index ( 28552196)	Adult body size ( 32376654) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (sex interaction) ( 24824216) Atrial fibrillation ( 30061737 29892015) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28892062 25673413) Body mass index (change over time) ( 25133637) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Breast cancer ( 22452962) Coronary artery calcification ( 23870195) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Glomerular filtration rate ( 29403010) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Liver fibrosis in non-alcoholic fatty acid liver disease ( 31311600) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Metabolite levels ( 23823483) Personality dimensions ( 23903073) Polycystic ovary syndrome ( 32289280 26416764) Positive urgency ( 30718321) QT interval (ambient particulate matter interaction) ( 28749367) Skin aging (microtopography measurement) ( 28502801) Sperm motility ( 29453196) Systolic blood pressure ( 30224653) Thyroxine levels ( 30843173) Total intracranial volume ( 31530798) Triiodothyronine levels ( 30843173) Type 1 diabetes nephropathy ( 23028342) Urate levels ( 31578528)
Interacting Genes		6 interacting genes: ERBB3 ERBB4 NEFL ROR2 SBF1 SNTA1	149 interacting genes: ABL1 ABL2 ADAM17 ALDOA ANKS1A ANKS1B BCAR3 BLK BTC CCN2 CD44 CDC25C CFL1 CRK DLG1 DLG2 DLG3 DLG4 DUSP10 DUSP14 DUSP16 DUSP18 DUSP19 DUSP21 DUSP6 EGFR ERBB2 ERBB3 EREG ERG28 FAM241B FES FGR FKBP1A GABARAPL2 GRAP2 GRB10 GRB2 GRB7 HBEGF HCK HDAC6 HSH2D ILKAP INPPL1 IRF2BP2 ITCH ITK LCK LCP2 LRRC7 LYN MATK MTMR2 MTMR6 MTMR9 MUC1 MUC4 NCK1 NCK2 NEDD4 NRG1 NRG2 NRG3 NRG4 NTRK2 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PRDX5 PRRG4 PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN21 PTPN6 PTPN7 PTPRH PTPRR PTPRT RASA1 RNF41 RTN4 S100A11 SELENOK SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNTB2 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SRC STAP1 STAT5A STAT5B STYX SYK SYNM TAB1 TAB2 TEC TFAP2C TGFA TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TRO TVP23B TXK TXN VAV1 VAV2 VAV3 WWOX YAP1 YES1 ZAP70 ZNF532
Entrez ID		8898	2066
HPRD ID		04650	02767
Ensembl ID		ENSG00000087053	ENSG00000178568
Uniprot IDs		A0A024R3B7 Q13614	Q15303
PDB IDs		1LW3 1M7R 1ZSQ 1ZVR 5GNH	2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U
Enriched GO Terms of Interacting Partners?
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