ERBB4 and WWOX

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		ERBB4	WWOX
Description		erb-b2 receptor tyrosine kinase 4	WW domain containing oxidoreductase
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Receptor Complex Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity	Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding
	Biological Process	MAPK Cascade Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Synapse Assembly Heart Development Lactation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Regulation Of Cell Migration Positive Regulation Of Kinase Activity ERBB2 Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Mitochondrial Fragmentation Involved In Apoptotic Process Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Autophosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Localization To Cell Surface Regulation Of Cell Motility Negative Regulation Of Neuron Migration	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Skeletal System Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
Drugs		Afatinib Fostamatinib Brigatinib Zanubrutinib
Diseases
GWAS		Adult body size ( 32376654) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (sex interaction) ( 24824216) Atrial fibrillation ( 30061737 29892015) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28892062 25673413) Body mass index (change over time) ( 25133637) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Breast cancer ( 22452962) Coronary artery calcification ( 23870195) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Glomerular filtration rate ( 29403010) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Liver fibrosis in non-alcoholic fatty acid liver disease ( 31311600) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Metabolite levels ( 23823483) Personality dimensions ( 23903073) Polycystic ovary syndrome ( 32289280 26416764) Positive urgency ( 30718321) QT interval (ambient particulate matter interaction) ( 28749367) Skin aging (microtopography measurement) ( 28502801) Sperm motility ( 29453196) Systolic blood pressure ( 30224653) Thyroxine levels ( 30843173) Total intracranial volume ( 31530798) Triiodothyronine levels ( 30843173) Type 1 diabetes nephropathy ( 23028342) Urate levels ( 31578528)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Alzheimer's disease (late onset) ( 30820047) Anorexia nervosa ( 23568457) Bipolar disorder (body mass index interaction) ( 24322204) Brain morphology (MOSTest) ( 32665545) Brain volume in infants (white matter) ( 28763065) Cardiac structure and function ( 19584346) Clozapine-induced cytotoxicity ( 25656473) Colorectal cancer ( 30529582 29228715) Daytime sleep phenotypes ( 27126917) Diffusing capacity of carbon monoxide ( 30694715) Early-onset Parkinson's disease ( 28256260) Eosinophil counts ( 32888494) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Familial squamous cell lung carcinoma ( 29924316) FEV1 ( 30804560) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip shape (DXA scan) ( 30320955) Idiopathic dilated cardiomyopathy ( 29495422) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Metabolite levels ( 23823483) Metabolite levels (5-HIAA) ( 23319000) Molybdenum levels ( 26025379) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 24076602) Obesity ( 21552555) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Platelet count ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Radiation response ( 20923822) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Serum thyroid-stimulating hormone levels ( 25436638) Serum uric acid levels in response to allopurinol in gout ( 25676789) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Systemic juvenile idiopathic arthritis ( 27927641) Type 2 diabetes ( 22158537) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		149 interacting genes: ABL1 ABL2 ADAM17 ALDOA ANKS1A ANKS1B BCAR3 BLK BTC CCN2 CD44 CDC25C CFL1 CRK DLG1 DLG2 DLG3 DLG4 DUSP10 DUSP14 DUSP16 DUSP18 DUSP19 DUSP21 DUSP6 EGFR ERBB2 ERBB3 EREG ERG28 FAM241B FES FGR FKBP1A GABARAPL2 GRAP2 GRB10 GRB2 GRB7 HBEGF HCK HDAC6 HSH2D ILKAP INPPL1 IRF2BP2 ITCH ITK LCK LCP2 LRRC7 LYN MATK MTMR2 MTMR6 MTMR9 MUC1 MUC4 NCK1 NCK2 NEDD4 NRG1 NRG2 NRG3 NRG4 NTRK2 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PRDX5 PRRG4 PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN21 PTPN6 PTPN7 PTPRH PTPRR PTPRT RASA1 RNF41 RTN4 S100A11 SELENOK SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNTB2 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SRC STAP1 STAT5A STAT5B STYX SYK SYNM TAB1 TAB2 TEC TFAP2C TGFA TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TRO TVP23B TXK TXN VAV1 VAV2 VAV3 WWOX YAP1 YES1 ZAP70 ZNF532	116 interacting genes: ABHD11 ABI2 ACAT2 ACY1 ADRA2C ANAPC11 ANXA11 APBB2 ARRDC3 C10orf55 C11orf87 C19orf54 CCDC24 CEACAM6 CLNK CNNM3 CPSF2 CPSF6 CPSF7 CREB5 CSNK2B CTAG1A CTAG1B CTDSP1 DAZAP2 DMRT3 ENKD1 ERBB4 EZR FAM214B FAM222B FEM1A FIP1L1 FOXD4L1 FOXI1 FRS3 GCM2 GEM GLIS2 GNE HNRNPK HOXA1 HOXC8 HSPB2 HSPB2-C11orf52 HYAL2 IFIT2 INCA1 KLHDC7B KLHL38 KRT3 KRT34 KRT75 KRTAP11-1 LASP1 LATS1 LITAF LMO3 MAPK8 MED25 MKRN3 MYG1 MYOZ1 MYOZ2 NEDD9 NUDT21 OLIG3 OTX1 PATL1 PATZ1 PAX9 PBX4 PEF1 PITX2 PLAC8 PLEKHN1 PLSCR3 PPP1R32 PSMB8 RAMAC RUSC1 SAXO1 SCAMP3 SEC23IP SF3B3 SH2D4A SHC3 SLC15A2 SMAD4 SMR3A SNRPC SRC TCERG1 TCHP TEKT3 TEX37 TFAP2C TFG TNK2 TP53 TP73 TRIM69 TSGA10IP UBB UFSP1 VENTX VEZF1 VPS37C WDR33 WIPF2 YPEL3 ZBTB32 ZIC1 ZNF135 ZNF414 ZNF581
Entrez ID		2066	51741
HPRD ID		02767	05501
Ensembl ID		ENSG00000178568	ENSG00000186153
Uniprot IDs		Q15303	A0A411HBC7 Q9NZC7
PDB IDs		2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U	1WMV
Enriched GO Terms of Interacting Partners?
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