EIF2S2 and TNFRSF25

Data Source:
BioGRID (affinity chromatography technology)

		EIF2S2	TNFRSF25
Description		eukaryotic translation initiation factor 2 subunit beta	TNF receptor superfamily member 25
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Translation Initiation Factor Binding Metal Ion Binding	Tumor Necrosis Factor-activated Receptor Activity Signaling Receptor Activity
	Biological Process	In Utero Embryonic Development Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Male Germ Cell Proliferation Translational Initiation Male Gonad Development Transmembrane Transport	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	TNFs bind their physiological receptors
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Diseases
GWAS		Breast cancer ( 22976474) Estimated glomerular filtration rate in non-diabetics ( 31451708) Refractive error ( 32231278) Skin pigmentation ( 28300201) Type 2 diabetes ( 30054458)
Interacting Genes		23 interacting genes: APLP1 APP CCDC90B CEP126 CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 ESR1 HMGA1 NCK1 PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16	8 interacting genes: BAG4 DAP3 MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2
Entrez ID		8894	8718
HPRD ID		04882	04532
Ensembl ID		ENSG00000125977	ENSG00000215788
Uniprot IDs		P20042 Q6IBR8	Q93038
PDB IDs		6K71 6K72 6YBV 6ZMW 6ZP4 7A09	5YGP 5YGS
Enriched GO Terms of Interacting Partners?
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