SYNJ2 and ITSN2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SYNJ2	ITSN2
Description		synaptojanin 2	intersectin 2
Image
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cell Projection Membrane Raft Perinuclear Region Of Cytoplasm Presynapse	Cytoplasm Centrosome Plasma Membrane Clathrin-coated Pit Presynaptic Membrane Extracellular Exosome Intracellular Vesicle Presynapse
	Molecular Function	RNA Binding Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding PDZ Domain Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Molecular Adaptor Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Brain Development Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Membrane Organization	Endocytosis Viral Process Endosomal Transport Cell Differentiation Regulation Of Catalytic Activity Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension
Pathways		Synthesis of PIPs at the plasma membrane Clathrin-mediated endocytosis	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Cannabis use (initiation) ( 22823124) Gamma glutamyl transferase levels ( 29403010) Intraocular pressure ( 29617998) Lipoprotein (a) levels ( 26377243) Platelet distribution width ( 32888494)	Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) SjÃ¶gren's syndrome ( 24097067)
Interacting Genes		6 interacting genes: GRB2 ITSN1 ITSN2 NCK1 RAC1 SYNJ2BP	75 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS15L1 EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		8871	50618
HPRD ID		10259	09193
Ensembl ID		ENSG00000078269	ENSG00000198399
Uniprot IDs		A0A1W2PR85 B4DG94 O15056	A6H8W8 Q9NZM3
PDB IDs		1UFW	1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO
Enriched GO Terms of Interacting Partners?
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