ITSN2 and LARP6

Data Source:
BioGRID (two hybrid)

		ITSN2	LARP6
Description		intersectin 2	La ribonucleoprotein 6, translational regulator
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GO Annotations	Cellular Component	Cytoplasm Centrosome Plasma Membrane Clathrin-coated Pit Presynaptic Membrane Extracellular Exosome Intracellular Vesicle Presynapse	Nucleus Cytoplasm Polysome Ribonucleoprotein Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Molecular Adaptor Activity	Protein Binding Myosin Binding RNA Stem-loop Binding MRNA 5'-UTR Binding Sequence-specific MRNA Binding
	Biological Process	Endocytosis Viral Process Endosomal Transport Cell Differentiation Regulation Of Catalytic Activity Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Dendrite Extension	RNA Processing Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Translation Positive Regulation Of MRNA Binding
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Asthma ( 29273806) Chromium levels ( 26025379) Diffuse large B cell lymphoma ( 25261932) Feeling fed-up ( 29500382) Low density lipoprotein cholesterol levels ( 32154731) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) SjÃ¶gren's syndrome ( 24097067)	Insulin-related traits (multivariate analysis) ( 32002517) Proinsulin levels ( 21873549)
Interacting Genes		75 interacting genes: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DST EGFR EPS15L1 EPS8 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREM2 GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO UBC WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1	4 interacting genes: APP ITSN2 MIR141 MIR145
Entrez ID		50618	55323
HPRD ID		09193	10966
Ensembl ID		ENSG00000198399	ENSG00000166173
Uniprot IDs		A6H8W8 Q9NZM3	Q9BRS8
PDB IDs		1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO	2MTF 2MTG
Enriched GO Terms of Interacting Partners?
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