AKAP4 and PRKAR2B

Data Source:
HPRD (two hybrid, in vitro)

		AKAP4	PRKAR2B
Description		A-kinase anchoring protein 4	protein kinase cAMP-dependent type II regulatory subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton CAMP-dependent Protein Kinase Complex Z Disc Motile Cilium Sperm Fibrous Sheath Perinuclear Region Of Cytoplasm Sperm Connecting Piece Sperm Midpiece Sperm Principal Piece Sperm End Piece	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Neuronal Cell Body Dendritic Spine Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Kinase A Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Single Fertilization Protein Localization Flagellated Sperm Motility Motile Cilium Assembly Establishment Of Protein Localization	G2/M Transition Of Mitotic Cell Cycle Renal Water Homeostasis Fatty Acid Metabolic Process Blood Coagulation Learning Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase A Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Regulation Of CAMP-mediated Signaling Modulation Of Chemical Synaptic Transmission Cellular Response To Glucagon Stimulus Response To Antipsychotic Drug Response To Clozapine Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			Cyclic adenosine monophosphate
Diseases
GWAS			Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: AKAP3 FSIP1 FSIP2 PRKAR1A PRKAR2A PRKAR2B	18 interacting genes: AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 C2orf88 CFAP91 ECM1 GNAI3 KIF5B LASP1 NBEA PAK1IP1 PRKACA TAF12
Entrez ID		8852	5577
HPRD ID		02173	01486
Ensembl ID		ENSG00000147081	ENSG00000005249
Uniprot IDs		A0A384MQY7 Q5JQC9	A0A024R712 B3KY43 P31323
PDB IDs
Enriched GO Terms of Interacting Partners?
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