LIN7A and SLC6A12

Data Source:
HPRD (in vitro, in vivo)

		LIN7A	SLC6A12
Description		lin-7 homolog A, crumbs cell polarity complex component	solute carrier family 6 member 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse Extracellular Exosome MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection
	Molecular Function	Protein Binding L27 Domain Binding	Gamma-aminobutyric Acid:sodium Symporter Activity Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity
	Biological Process	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Synaptic Vesicle Transport Inner Ear Development Protein-containing Complex Assembly Protein Localization To Basolateral Plasma Membrane	Amino Acid Transmembrane Transport Neurotransmitter Transport Amino Acid Transport Monocarboxylic Acid Transport Gamma-aminobutyric Acid Transport Sodium Ion Transmembrane Transport
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Amino acid transport across the plasma membrane Na+/Cl- dependent neurotransmitter transporters Creatine metabolism Reuptake of GABA
Drugs			Guvacine
Diseases
GWAS		Age-related cataracts (age at onset) ( 25352737) Dental caries ( 23259602)	Blood metabolite levels ( 24816252) Chronic kidney disease ( 20383146) Diisocyanate-induced asthma ( 25918132) Metabolite levels ( 23823483 23378610)
Interacting Genes		24 interacting genes: ABCA1 ADGRB1 APP BAIAP2 CASK CHRD DLG2 DLG3 DLG4 DNAJC5 ECM1 FAM9B GOLGA2 GRIN2B KCNJ12 MDFI MPP2 MPP3 MPP7 NOTCH2NLA PALS1 PALS2 SLC6A12 ZYX	4 interacting genes: CD79A ERBIN LIN7A REL
Entrez ID		8825	6539
HPRD ID		04542	04358
Ensembl ID		ENSG00000111052	ENSG00000111181
Uniprot IDs		O14910	P48065
PDB IDs
Enriched GO Terms of Interacting Partners?
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