EDF1 and NR1H3

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro)

		EDF1	NR1H3
Description		endothelial differentiation related factor 1	nuclear receptor subfamily 1 group H member 3
Image
GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	TFIID-class Transcription Factor Complex Binding DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Calmodulin Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Sterol Response Element Binding
	Biological Process	Regulation Of Transcription, DNA-templated Multicellular Organism Development Regulation Of Lipid Metabolic Process Positive Regulation Of DNA Binding Endothelial Cell Differentiation Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways			PPARA activates gene expression VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs			TO-901317 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Diacerein Rhein
Diseases
GWAS			Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood glucose levels ( 31928498) Creatinine levels ( 29403010) Feeling miserable ( 29500382) HDL cholesterol ( 19060910 20686565) Hypertension ( 31879980) Intraocular pressure ( 29785010) Lymphocyte percentage of white cells ( 27863252) Metabolic syndrome ( 22399527) Monocyte percentage of white cells ( 27863252) Mood instability ( 31168069) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Triglyceride levels ( 32154731) Triglycerides ( 30275531)
Interacting Genes		22 interacting genes: ATF1 ATF2 CALM1 CALM2 CALM3 CDC42 CEBPA CREB1 JUN MAPK6 MEOX2 NR1H3 NR5A1 NR5A2 NRL PPARG PRKCA RXRA SOX4 TAF1 TBP UBE2I	35 interacting genes: ACTN1 APP BAG3 CEP350 EDF1 FOXO3 GPANK1 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA PPARD PPARG PSMC5 RARA RXRA RXRB RXRG SIRT1 SS18L1 SUV39H1 SYT1 TMEM161A UBE2I ZXDC
Entrez ID		8721	10062
HPRD ID		09235	07211
Ensembl ID		ENSG00000107223	ENSG00000025434
Uniprot IDs		O60869	B4DXU5 B5MBY7 F1D8N1 Q13133
PDB IDs		1X57 6ZVH	1UHL 3IPQ 3IPS 3IPU 5AVI 5AVL 5HJS
Enriched GO Terms of Interacting Partners?
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