NOL4 and SUZ12

Data Source:
BioGRID (affinity chromatography technology)

		NOL4	SUZ12
Description		nucleolar protein 4	SUZ12 polycomb repressive complex 2 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus	Nucleus Nucleoplasm Nucleolus Nuclear Body ESC/E(Z) Complex
	Molecular Function	RNA Binding	RNA Polymerase II Transcription Corepressor Binding Protein Binding Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K27 Specific)
	Biological Process		Spinal Cord Development Response To Retinoic Acid Negative Regulation Of Chemokine Production Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Trimethylation
Pathways			PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs
Diseases
GWAS		Breast size ( 22747683) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Neurociticism ( 29500382) Response to citalopram treatment ( 19846067) Schizophrenia ( 30285260) Urate levels in overweight individuals ( 25811787)	High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		16 interacting genes: AKT1 C1QTNF2 CHMP2A CTBP1 CTBP2 FAM9B MAGEA11 MAPK6 MEOX2 P4HB PRMT1 SKA3 SNAPC5 SYCE1L TEX9 ZNF383	17 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 CTCF EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 UBE2I WDR77
Entrez ID		8715	23512
HPRD ID		04657	06949
Ensembl ID		ENSG00000101746	ENSG00000178691
Uniprot IDs		B3KRF4 B4DLW2 O94818	J3QQW9 Q15022
PDB IDs			4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3
Enriched GO Terms of Interacting Partners?
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