Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
BECN1 and TSC1
Data Source:
BioGRID
(fluorescent resonance energy transfer)
BECN1
TSC1
Description
beclin 1
TSC complex subunit 1
Image
GO Annotations
Cellular Component
Phagophore Assembly Site
Nucleus
Mitochondrion
Endosome
Autophagosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Trans-Golgi Network
Cytosol
Endosome Membrane
Extrinsic Component Of Membrane
Dendrite
Mitochondrial Membrane
Phosphatidylinositol 3-kinase Complex, Class III, Type I
Phosphatidylinositol 3-kinase Complex, Class III, Type II
Phosphatidylinositol 3-kinase Complex, Class III
Phagocytic Vesicle
Nucleus
Cytoplasm
Lipid Droplet
Cytosol
Actin Filament
Plasma Membrane
Cell Cortex
Postsynaptic Density
Membrane
Lamellipodium
Growth Cone
Protein-containing Complex
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Chaperone Complex
Molecular Function
Protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphatidylinositol 3-kinase Binding
GTPase Binding
Protein Binding
Hsp70 Protein Binding
GTPase Activating Protein Binding
ATPase Inhibitor Activity
Protein-containing Complex Binding
Protein N-terminus Binding
Chaperone Binding
Hsp90 Protein Binding
Biological Process
Autophagosome Assembly
Autophagy Of Mitochondrion
Mitophagy
Response To Hypoxia
Autophagy
Apoptotic Process
Cellular Defense Response
Cellular Response To Nitrogen Starvation
Lysosome Organization
Mitotic Metaphase Plate Congression
Aging
Negative Regulation Of Cell Population Proliferation
Response To Iron(II) Ion
Response To Lead Ion
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Macroautophagy
Protein Deubiquitination
Regulation Of Cytokinesis
Receptor Catabolic Process
Response To Vitamin E
Cellular Response To Amino Acid Starvation
Cellular Response To Glucose Starvation
Response To Drug
Negative Regulation Of Apoptotic Process
Engulfment Of Apoptotic Cell
Early Endosome To Late Endosome Transport
Late Endosome To Vacuole Transport
Neuron Development
Amyloid-beta Metabolic Process
Regulation Of Catalytic Activity
Cell Division
Defense Response To Virus
Negative Regulation Of Cell Death
Cellular Response To Hydrogen Peroxide
Cellular Response To Aluminum Ion
Cellular Response To Copper Ion
Cellular Response To Epidermal Growth Factor Stimulus
Response To Mitochondrial Depolarisation
Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Negative Regulation Of Autophagosome Assembly
Negative Regulation Of Lysosome Organization
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Autophagosome Assembly
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Kidney Development
Neural Tube Closure
Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
RRNA Export From Nucleus
Regulation Of Translation
Potassium Ion Transport
Cell-matrix Adhesion
Negative Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Negative Regulation Of Neuron Projection Development
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Negative Regulation Of Translation
Hippocampus Development
Cerebral Cortex Development
Cell Projection Organization
Negative Regulation Of TOR Signaling
Negative Regulation Of ATPase Activity
Response To Insulin
Negative Regulation Of GTPase Activity
Myelination
Memory T Cell Differentiation
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Cell Size
Regulation Of Protein Kinase Activity
Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Synapse Organization
Protein Stabilization
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Cycle
Positive Regulation Of Focal Adhesion Assembly
Cardiac Muscle Cell Differentiation
Activation Of GTPase Activity
Cellular Response To Oxygen-glucose Deprivation
Regulation Of Neuron Death
Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways
Macroautophagy
Ub-specific processing proteases
Translation of Replicase and Assembly of the Replication Transcription Complex
Translation of Replicase and Assembly of the Replication Transcription Complex
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs
Drugs
Estradiol
Estradiol acetate
Estradiol benzoate
Estradiol cypionate
Estradiol dienanthate
Estradiol valerate
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Type 2 diabetes (age of onset) (
28060188
)
Migraine without aura (
23793025
)
Psoriasis (
19169254
)
Interacting Genes
59 interacting genes:
AKT1
AMBRA1
ARAF
ARNT
ATG3
BCL2
BCL2L1
BCL2L10
BTK
CASP3
CCND2
CDK4
CDK6
CDKN2A
CDKN2B
EPHA2
ERBB2
FGFR4
FRS2
FZR1
GFI1B
GLIS2
GOPC
GRM1
HERC5
ITCH
ITPR1
ITPR3
KAT2A
KDELR2
LATS2
MAP2K3
MAP2K5
MAP2K6
MAPKAPK2
MAPKAPK3
MDM4
MST1
NF2
NXF1
PDGFRA
PGK1
RACK1
RAF1
SENP3
SGF29
SHD
SMAD2
STK11
STYK1
TEAD2
TERT
TRAF2
TSC1
UBC
ULK1
WASHC1
XPO1
YES1
99 interacting genes:
AKT1
APPL2
AQP1
ARAF
ARID5A
ATXN1
AURKA
BAG3
BECN1
C1orf94
CCDC120
CCL28
CCNB1
CCND2
CCNE1
CDK1
CDK4
CDK6
CDKN2A
CDKN2B
CHCHD2
CSTF2
DMRT3
DOK5
ENKD1
EZR
FAM110A
FAM222B
FGFR4
FOXH1
FRS3
GLIS2
GPANK1
HOXC8
HR
HSH2D
IGFN1
IKBKB
KAT2A
KDM1A
LATS2
LENG1
LMO2
MAP2K5
MAPK14
MSN
MYC
MYLIP
MYOZ3
NEFL
NF2
PATL1
PATZ1
PITX1
PLK1
PLK2
POGZ
POU6F2
PPP1R18
PPP1R32
PRMT6
RASSF1
RBPMS
RDX
RHEB
RIN1
RIN3
SAMD11
SAMD7
SH2D2A
SHC3
SMG9
SOX4
SPAG8
SUOX
TBC1D7
TBX6
TCF7L2
TFAP2D
TLE5
TNS2
TSC2
TSGA10IP
TSHZ3
VENTX
VEZF1
VGLL3
VPS37C
YPEL3
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZIC1
ZNF417
ZNF587
ZNF765
Entrez ID
8678
7248
HPRD ID
05087
05594
Ensembl ID
ENSG00000126581
ENSG00000165699
Uniprot IDs
A0A024R1X5
B4DQ36
E7EV84
Q14457
W0FFG4
A0A2R8Y5S3
Q32NF0
Q86WV8
Q92574
X5D9D2
PDB IDs
2P1L
2PON
3DVU
4DDP
4MI8
5EFM
5HHE
5VAU
5VAX
5VAY
6DCN
6DCO
6HOI
6HOJ
6HOK
4Z6Y
5EJC
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?