CADPS and PRPF18

Data Source:
BioGRID (two hybrid)

		CADPS	PRPF18
Description		calcium dependent secretion activator	pre-mRNA processing factor 18
Image
GO Annotations	Cellular Component	Cytosol Presynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Membrane	Nucleus Spliceosomal Complex U5 SnRNP Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Post-spliceosomal Complex
	Molecular Function	Protein Binding Lipid Binding Protein Kinase Binding Metal Ion Binding	Protein Binding
	Biological Process	Exocytosis Protein Transport Synaptic Vesicle Exocytosis Positive Regulation Of Exocytosis Dense Core Granule Exocytosis	Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA Processing RNA Splicing Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription
Pathways
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Adult body size ( 32376654) Autism spectrum disorder ( 30804558) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast size ( 22747683 27182965) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Economic and political preferences (environmentalism) ( 22566634) Fasting plasma glucose ( 31932636) Hand grip strength ( 29691431) Lung function (FEV1/FVC) ( 30061609) Meat-related diet ( 32066663) Metabolite levels (X-11787) ( 23934736) Obsessive-compulsive symptoms ( 26859814) Optic disc size ( 31809533) Pre-treatment viral load in HIV-1 infection ( 31219150) Processed meat consumption ( 32066663) QT interval (sulfonylurea treatment interaction) ( 27958378) Risk-taking tendency (4-domain principal component model) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Trunk fat mass ( 28552196)	Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) Craniofacial microsomia ( 26853712) Lupus nephritis in systemic lupus erythematosus ( 24925725) Post bronchodilator FEV1/FVC ratio ( 26634245) Skin pigmentation ( 28300201)
Interacting Genes		43 interacting genes: ACTN3 ANKS1A AURKC C17orf67 CABP5 CCDC120 CCDC185 DMD DNAJC5 DRD2 FAM161A FAM90A1 FAM9B FANCL FOXD2 GADD45GIP1 GPANK1 GSE1 HDAC4 HOXB5 HOXC8 KANK2 KIAA1549 LNX1 LUC7L2 OLIG3 PIP5K1A PNMA5 PRPF18 SDCBP SEC23A SH2D4A SHFL TCL1A TENT2 TRIM55 TRIM63 TSEN2 TTLL10 USP2 ZFC3H1 ZNF572 ZNF688	81 interacting genes: AGTRAP AMOTL2 AP2M1 ASCC2 BEGAIN BICD2 BLZF1 CADPS CALCOCO2 CARD10 CARD9 CBY2 CCDC102B CCDC136 CCDC150 CCDC57 CCNC CDR2 CEP70 CSRNP1 DVL3 EFHC2 EVI5L FERMT3 FSD2 GAS8 GCC1 GOLGA2 GOLGA6L9 GPBP1 GRIPAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKBKG IKZF1 KANK2 KCTD7 KIFC3 KRT31 KRT34 KRT35 KRT39 KRT40 LDOC1 LZTS1 LZTS2 MCC MDFI MEOX2 MTUS2 NACC1 NECAB2 NINL NUTM1 NUTM2F OSBPL3 PDE9A PFDN5 PIBF1 PICK1 PLEKHG4 PNMA1 PPIH PRKAR1B RHOU RINT1 SCHIP1 SPRED1 STX11 TRAF2 TRIM23 TRIM27 TRIM54 TSNAX TSNAXIP1 UBXN11 ZNF526 ZNF639 ZRANB1
Entrez ID		8618	8559
HPRD ID		05236	05407
Ensembl ID		ENSG00000163618	ENSG00000165630
Uniprot IDs		F1T0E5 Q9ULU8	Q99633
PDB IDs		1WI1	2DK4
Enriched GO Terms of Interacting Partners?
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