MKNK1 and FANCA

Data Source:
BioGRID (two hybrid)

		MKNK1	FANCA
Description		MAPK interacting serine/threonine kinase 1	FA complementation group A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding
	Biological Process	Regulation Of Translation Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	DNA Repair Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Cell Population Proliferation Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex Assembly Regulation Of CD40 Signaling Pathway
Pathways		Spry regulation of FGF signaling	Fanconi Anemia Pathway
Drugs		Fostamatinib
Diseases			Fanconi anemia
GWAS		Schizophrenia ( 26198764) Triglyceride levels ( 31170924)	Brain morphology (MOSTest) ( 32665545) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 31959993 30054594) Low tan response ( 29739929) Monocyte percentage of white cells ( 32888494) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)
Interacting Genes		26 interacting genes: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1	48 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 HSP90AA1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24
Entrez ID		8569	2175
HPRD ID		09468	06186
Ensembl ID		ENSG00000079277	ENSG00000187741
Uniprot IDs		A8K341 Q7Z319 Q9BUB5	O15360
PDB IDs		2HW6 2Y9Q 5WVD
Enriched GO Terms of Interacting Partners?
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