FANCA and LIPG

Data Source:
BioGRID (two hybrid)

		FANCA	LIPG
Description		FA complementation group A	lipase G, endothelial type
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Fanconi Anaemia Nuclear Complex	Extracellular Region Extracellular Space Early Endosome Golgi Apparatus Cell Surface
	Molecular Function	Protein Binding	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Heparin Binding Phospholipase A1 Activity Lipase Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity
	Biological Process	DNA Repair Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Cell Population Proliferation Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Protein-containing Complex Assembly Regulation Of CD40 Signaling Pathway	Lipid Metabolic Process Fatty Acid Biosynthetic Process Response To Nutrient Cell Population Proliferation Phospholipid Catabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Lipid Catabolic Process Triglyceride Catabolic Process Positive Regulation Of Cholesterol Transport High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis Reverse Cholesterol Transport Regulation Of Lipoprotein Metabolic Process Phospholipid Homeostasis
Pathways		Fanconi Anemia Pathway	HDL remodeling
Drugs
Diseases		Fanconi anemia
GWAS		Brain morphology (MOSTest) ( 32665545) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Intraocular pressure ( 29617998 29785010 31959993 30054594) Low tan response ( 29739929) Monocyte percentage of white cells ( 32888494) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Skin pigmentation traits ( 30166351)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Apolipoprotein A1 levels ( 32203549 29084231) Blood metabolite levels ( 24816252) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol ester levels in very large HDL ( 29084231) Cholesterol, total ( 24097068 19060911 25961943 20686565) Coronary artery disease ( 29212778) Free cholesterol levels in medium HDL ( 29084231) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 24097068 20031538 31170924 28270201 24507774 18193043 18193044 20864672 19060906 19060911 30275531 25961943 20686565 26582766) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29403010 31217584) Large HDL particle concentration ( 29084231) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219 19936222) Low density lipoprotein cholesterol levels ( 32154731) Mean diameter of HDL particles ( 29084231) Mean spheric corpuscular volume ( 32888494) Medium HDL particle concentration ( 29084231) Metabolic syndrome ( 31589552) Metabolite levels (lipoprotein measures) ( 27005778) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to selective serotonin reuptake inhibitors in depression ( 27622933) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Testicular germ cell tumor ( 23666239) Total cholesterol levels ( 28334899 29403010 30275531) Total cholesterol levels in HDL ( 29084231) Total cholesterol levels in large HDL ( 29084231)
Interacting Genes		48 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 HSP90AA1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24	2 interacting genes: EXOSC5 FANCA
Entrez ID		2175	9388
HPRD ID		06186	04730
Ensembl ID		ENSG00000187741	ENSG00000101670
Uniprot IDs		O15360	A0A024R2B5 B4DTR8 Q9Y5X9
PDB IDs
Enriched GO Terms of Interacting Partners?
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