CDC14B and SKP2

Data Source:
BioGRID (enzymatic study)

		CDC14B	SKP2
Description		cell division cycle 14B	S-phase kinase associated protein 2
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Mitotic Spindle	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle DNA Repair Protein Dephosphorylation Regulation Of Exit From Mitosis G2 DNA Damage Checkpoint Positive Regulation Of Cytokinesis Peptidyl-tyrosine Dephosphorylation Cilium Assembly Mitotic Cell Cycle Arrest Signal Transduction Involved In G2 DNA Damage Checkpoint Positive Regulation Of Ubiquitin Protein Ligase Activity	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Viral Process Protein Deubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Defense Response To Virus Regulation Of Cell Cycle Protein K48-linked Ubiquitination
Pathways		MAPK6/MAPK4 signaling	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Household income ( 31844048) Intelligence (MTAG) ( 29326435) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)	Birth weight ( 31043758) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 32888494 27863252)
Interacting Genes		19 interacting genes: BCL10 BUB1 CCND1 CDKN2A DLC1 MCC MFAP1 MLH3 MSH2 MTDH PRKAB2 PSMB1 SIRT2 SKP2 SMAD4 SPANXN2 STK11 TP53 ZNF696	64 interacting genes: AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 EP300 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NLK ORC1 PAX8 PDCD4 PFDN1 PIM1 POLR2A PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SLC9A3R1 SMAD4 SQSTM1 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1
Entrez ID		8555	6502
HPRD ID		04615	03256
Ensembl ID		ENSG00000081377	ENSG00000145604
Uniprot IDs		O60729	A0A024R069 Q13309
PDB IDs		1OHC 1OHD 1OHE	1FQV 1FS1 1FS2 1LDK 2ASS 2AST
Enriched GO Terms of Interacting Partners?
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