SKP2 and RAG2

Data Source:
BioGRID (enzymatic study)

		SKP2	RAG2
Description		S-phase kinase associated protein 2	recombination activating 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex	Nucleoplasm DNA Recombinase Complex
	Molecular Function	Protein Binding Identical Protein Binding	Chromatin Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Methylated Histone Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Sequence-specific DNA Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Viral Process Protein Deubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Defense Response To Virus Regulation Of Cell Cycle Protein K48-linked Ubiquitination	B Cell Lineage Commitment Pre-B Cell Allelic Exclusion B Cell Homeostatic Proliferation T Cell Lineage Commitment Chromatin Organization Protein Ubiquitination B Cell Differentiation T Cell Differentiation In Thymus V(D)J Recombination Defense Response To Bacterium Positive Regulation Of Organ Growth
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Interleukin-7 signaling MAPK6/MAPK4 signaling
Drugs
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Birth weight ( 31043758) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 32888494 27863252)	Rheumatoid arthritis ( 24390342)
Interacting Genes		64 interacting genes: AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 EP300 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NLK ORC1 PAX8 PDCD4 PFDN1 PIM1 POLR2A PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SLC9A3R1 SMAD4 SQSTM1 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1	3 interacting genes: IPO5 RAG1 SKP2
Entrez ID		6502	5897
HPRD ID		03256	08913
Ensembl ID		ENSG00000145604	ENSG00000175097
Uniprot IDs		A0A024R069 Q13309	P55895
PDB IDs		1FQV 1FS1 1FS2 1LDK 2ASS 2AST
Enriched GO Terms of Interacting Partners?
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