ALG2 and ANXA11

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro)

		ALG2	ANXA11
Description		ALG2 alpha-1,3/1,6-mannosyltransferase	annexin A11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Actin Cytoskeleton Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Nuclear Envelope Nucleoplasm Cytoplasm Spindle Cytosol Membrane Midbody Melanosome Specific Granule Azurophil Granule Phagocytic Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Alpha-1,3-mannosyltransferase Activity GDP-Man:Man1GlcNAc2-PP-Dol Alpha-1,3-mannosyltransferase Activity Protein Binding Protein Heterodimerization Activity Protein N-terminus Binding Calcium-dependent Protein Binding GDP-Man:Man2GlcNAc2-PP-dolichol Alpha-1,6-mannosyltransferase Activity	RNA Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding MHC Class II Protein Complex Binding S100 Protein Binding Calcium-dependent Protein Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein Glycosylation In Endoplasmic Reticulum Response To Calcium Ion Mannosylation	Phagocytosis Cytokinetic Process Response To Calcium Ion
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG2 causes ALG2-CDG (CDG-1i)
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Asthma ( 31959851) Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Diabetic kidney disease ( 26305897) Sarcoidosis ( 22936702) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848)
Interacting Genes		4 interacting genes: ANXA11 PEF1 PTPN23 SRI	18 interacting genes: ALG2 ARSA CDC42 CEP55 ENO2 EWSR1 FUBP1 HNRNPH3 KRTAP13-2 KRTAP6-2 NFKBID PDCD6 PLSCR1 S100A6 SRI TFG WWOX ZDHHC17
Entrez ID		85365	311
HPRD ID		09716	03983
Ensembl ID		ENSG00000119523	ENSG00000122359
Uniprot IDs		A0A024R184 Q9H553	P50995 Q5T0G8
PDB IDs
Enriched GO Terms of Interacting Partners?
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