SHANK3 and DLGAP4

Data Source:
BioGRID (two hybrid)

		SHANK3	DLGAP4
Description		SH3 and multiple ankyrin repeat domains 3	DLG associated protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Ionotropic Glutamate Receptor Complex Postsynaptic Density Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Ciliary Membrane	Plasma Membrane Neuromuscular Junction Glutamatergic Synapse Cholinergic Synapse Postsynaptic Specialization
	Molecular Function	Actin Binding Protein Binding Protein C-terminus Binding Zinc Ion Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding Protein Self-association Scaffold Protein Binding	Protein Binding Molecular Adaptor Activity
	Biological Process	MAPK Cascade Axon Guidance Synapse Assembly Behavior Learning Memory Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity	Signaling Regulation Of Postsynaptic Neurotransmitter Receptor Activity
Pathways			Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Platelet count ( 32888494)	Low density lipoprotein cholesterol levels ( 32154731) Neuroblastoma or malignant cutaneous melanoma ( 31605138)
Interacting Genes		17 interacting genes: ABCC2 CNKSR2 COPS5 CRKL CSNK2B DLGAP1 DLGAP2 DLGAP3 DLGAP4 GRB2 MAPK1 NCK1 PAX6 PPP1CC RPS6KA1 SPTAN1 USP8	32 interacting genes: ABI2 ALDH16A1 ATPAF2 BIN1 DLG1 DLG3 DLG4 EXOC4 FHL3 FHL5 FKBP6 FYN GRIN1 GRIN2D MAGEA6 MPP7 MTUS2 NCK1 NCK2 PALS1 PLP2 PPP1R1B SH3GL2 SH3RF1 SHANK2 SHANK3 SLC9A3R1 SLC9A3R2 SORBS2 SYNGAP1 UBASH3A UBC
Entrez ID		85358	22839
HPRD ID		18979	16826
Ensembl ID		ENSG00000251322	ENSG00000080845
Uniprot IDs			A0A0B4J2C2 Q9Y2H0
PDB IDs
Enriched GO Terms of Interacting Partners?
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