CYP4F2 and SLC17A8

Data Source:
BioGRID (two hybrid)

		CYP4F2	SLC17A8
Description		cytochrome P450 family 4 subfamily F member 2	solute carrier family 17 member 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle	Multivesicular Body Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Perikaryon Axon Terminus Excitatory Synapse Apical Dendrite Basal Dendrite Glial Limiting End-foot Pericellular Basket
	Molecular Function	Iron Ion Binding Protein Binding Arachidonic Acid Monooxygenase Activity Arachidonic Acid Epoxygenase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Alkane 1-monooxygenase Activity Heme Binding Leukotriene-B4 20-monooxygenase Activity Arachidonic Acid Omega-hydroxylase Activity Alpha-tocopherol Omega-hydroxylase Activity Tocotrienol Omega-hydroxylase Activity Aromatase Activity	L-glutamate Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Renal Water Homeostasis Pressure Natriuresis Icosanoid Metabolic Process Leukotriene Metabolic Process Blood Coagulation Regulation Of Blood Pressure Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Negative Regulation Of Icosanoid Secretion Positive Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process Phylloquinone Catabolic Process Vitamin K Catabolic Process Sodium Ion Homeostasis Omega-hydroxylase P450 Pathway	Neural Retina Development Ion Transport Sodium Ion Transport Anion Transport Brain Development Sensory Perception Of Sound L-glutamate Transmembrane Transport Synaptic Transmission, Glutamatergic Regulation Of Synapse Structure Or Activity Cochlea Development Neurotransmitter Loading Into Synaptic Vesicle
Pathways		Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	Organic anion transporters Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)
Drugs
Diseases
GWAS		Acenocoumarol maintenance dosage ( 19578179) Circulating phylloquinone levels ( 25411281) Metabolite levels ( 23281178) Response to Vitamin E supplementation ( 22437554) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Vitamin E levels ( 21729881) Warfarin maintenance dose ( 20833655 19300499)	Low density lipoprotein cholesterol levels ( 32154731) Squamous cell carcinoma ( 23341777)
Interacting Genes		36 interacting genes: - AQP6 CPLX4 CREB3 CREB3L1 DNAJC1 EBP ELOVL4 ERGIC3 FAM210B FCER1G GJA8 HSD17B13 JAGN1 LEPROTL1 MMD MTIF3 MUC1 PGRMC2 PLEKHO1 REEP2 REEP4 RETREG3 SCN3B SDHAF2 SLC10A6 SLC17A8 SLC19A3 SLC2A13 THAP4 TLCD4 TM4SF19 TMEM51 TMEM82 TMX2 UBE2I	4 interacting genes: CYP4F2 DNAJC5 TMEM120B YIPF6
Entrez ID		8529	246213
HPRD ID		05112	10457
Ensembl ID		ENSG00000186115	ENSG00000179520
Uniprot IDs		P78329	Q8NDX2
PDB IDs
Enriched GO Terms of Interacting Partners?
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