SLC17A8 and DNAJC5

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		SLC17A8	DNAJC5
Description		solute carrier family 17 member 8	DnaJ heat shock protein family (Hsp40) member C5
Image		No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Integral Component Of Membrane Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Perikaryon Axon Terminus Excitatory Synapse Apical Dendrite Basal Dendrite Glial Limiting End-foot Pericellular Basket	Mitochondrion Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Anchored Component Of Membrane Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	L-glutamate Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity	Protein Binding ATP-dependent Protein Binding
	Biological Process	Neural Retina Development Ion Transport Sodium Ion Transport Anion Transport Brain Development Sensory Perception Of Sound L-glutamate Transmembrane Transport Synaptic Transmission, Glutamatergic Regulation Of Synapse Structure Or Activity Cochlea Development Neurotransmitter Loading Into Synaptic Vesicle	Exocytosis Neurotransmitter Secretion Synaptic Vesicle Exocytosis Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Chaperone-mediated Protein Folding Regulation Of Synaptic Vesicle Cycle
Pathways		Organic anion transporters Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)	Neutrophil degranulation GABA synthesis, release, reuptake and degradation
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Squamous cell carcinoma ( 23341777)	Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: CYP4F2 DNAJC5 TMEM120B YIPF6	56 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CASK CD2 CFTR CGB5 CLCN3 EFNB1 ERC1 FAS FCHO1 GRM8 HBA2 HGS KHDC4 LIN7A LIN7C NECAP1 NRXN3 NUMB PPFIA1 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP1 SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 STX7 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7
Entrez ID		246213	80331
HPRD ID		10457	08539
Ensembl ID		ENSG00000179520	ENSG00000101152
Uniprot IDs		Q8NDX2	Q6AHX3 Q9H3Z4
PDB IDs			2N04 2N05
Enriched GO Terms of Interacting Partners?
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