FAM83A and PRDM14

Data Source:
BioGRID (two hybrid)

		FAM83A	PRDM14
Description		family with sequence similarity 83 member A	PR/SET domain 14
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Protein Kinase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Binding Protein Binding Methyltransferase Activity Chromatin DNA Binding Metal Ion Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Population Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Germ Cell Development Embryo Implantation Fertilization Regulation Of Gene Expression Germ-line Stem Cell Population Maintenance Histone H3-R26 Methylation Somatic Stem Cell Population Maintenance Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of DNA Methylation Homeostasis Of Number Of Cells Within A Tissue Inactivation Of Paternal X Chromosome Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance
Pathways			Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Urinary uromodulin levels ( 24578125)	Schizophrenia ( 30285260) Testicular germ cell tumor ( 28604728 28604732 23666240)
Interacting Genes		23 interacting genes: BHLHE40 CYSRT1 DAZAP2 FOXH1 FOXI1 GCC1 GPSM1 KRT34 KRTAP6-2 KRTAP6-3 KRTAP8-1 MAGED1 MGAT5B NCK2 PLAGL2 PPP1R16B PRDM14 PSMA3 QARS1 SMYD1 TRIM23 TRIM27 UBASH3A	67 interacting genes: ABI2 AKAP9 AQP1 ATPAF2 BAG4 BAHD1 BCAR3 BEX2 CARD10 CASP8 CBFA2T2 CDCA7L CHEK2 CREB5 DGCR6 DMRT3 EED EIF4E2 ENKD1 ERBB2 EZH2 FAM83A GAS8 GEM GLYCTK GPATCH2L HEXIM2 HOXB5 HOXC8 HSPB7 ID3 IDH1 KANK2 LNX1 MIA3 MRPL32 MYPOP PALB2 PATZ1 PAX2 PLEKHF2 PPP1R32 PRKAB2 PRPF31 PSMA1 PTPRJ RAD51D RBM10 RCOR3 RUNX1T1 RUSC1 SCNM1 SNRPC SUZ12 TCAF1 TEAD4 TEKT4 TLE5 TRIM41 TSGA10 TTC32 TXK USP2 WDR25 ZNF250 ZNF587 ZNF835
Entrez ID		84985	63978
HPRD ID		17489	11457
Ensembl ID		ENSG00000147689	ENSG00000147596
Uniprot IDs		Q86UY5	Q9GZV8
PDB IDs		4URJ
Enriched GO Terms of Interacting Partners?
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