ZNRF1 and ATP1A1

Data Source:
BioGRID (enzymatic study)

		ZNRF1	ATP1A1
Description		zinc and ring finger 1	ATPase Na+/K+ transporting subunit alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Endosome Cytosol Membrane Synaptic Vesicle Membrane	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Postsynaptic Density Intercalated Disc Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Protein-containing Complex Sperm Flagellum Sarcolemma Melanosome Membrane Raft Photoreceptor Inner Segment Membrane Extracellular Exosome Extracellular Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	P-type Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Potassium Ion Binding Sodium Ion Binding ADP Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity Chaperone Binding Steroid Hormone Binding
	Biological Process	Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Cellular Sodium Ion Homeostasis Regulation Of Blood Pressure Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Dephosphorylation Cellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Response To Drug Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Relaxation Of Cardiac Muscle Membrane Hyperpolarization Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Digoxin Acetyldigitoxin Hydroflumethiazide Etacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Ciclopirox Bepridil Potassium cation Aluminium Magnesium cation Digitoxin Almitrine Istaroxime Magnesium acetate Potassium acetate Potassium sulfate Potassium Magnesium levulinate Magnesium lactate Aluminium phosphate Aluminum acetate
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)	Coffee consumption ( 29367735) Macular thickness ( 30535121)
Interacting Genes		15 interacting genes: ATP1A1 CDC34 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W UBXN7	18 interacting genes: A2M ADD1 CFL1 EGFR EZH2 FXYD1 FXYD2 FXYD7 GPR35 HGS MAPK1 MAPK3 NDRG1 PRKCA SNAPIN TPT1 ZNRF1 ZNRF2
Entrez ID		84937	476
HPRD ID		15893	01662
Ensembl ID		ENSG00000186187	ENSG00000163399
Uniprot IDs		Q8ND25	P05023
PDB IDs		5YWR
Enriched GO Terms of Interacting Partners?
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