ATP1A1 and TPT1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ATP1A1	TPT1
Description		ATPase Na+/K+ transporting subunit alpha 1	tumor protein, translationally-controlled 1
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Postsynaptic Density Intercalated Disc Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Protein-containing Complex Sperm Flagellum Sarcolemma Melanosome Membrane Raft Photoreceptor Inner Segment Membrane Extracellular Exosome Extracellular Vesicle	Spindle Pole Extracellular Space Nucleus Cytoplasm Multivesicular Body Cytosol Cytoplasmic Microtubule Extracellular Exosome
	Molecular Function	P-type Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Potassium Ion Binding Sodium Ion Binding ADP Binding Phosphatidylinositol 3-kinase Binding Protein Heterodimerization Activity Chaperone Binding Steroid Hormone Binding	RNA Binding Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Cellular Sodium Ion Homeostasis Regulation Of Blood Pressure Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Dephosphorylation Cellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Response To Drug Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Relaxation Of Cardiac Muscle Membrane Hyperpolarization Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Proton Transmembrane Transport Response To Glycoside Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane	Calcium Ion Transport Cellular Calcium Ion Homeostasis Response To Virus Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs		Digoxin Acetyldigitoxin Hydroflumethiazide Etacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Ciclopirox Bepridil Potassium cation Aluminium Magnesium cation Digitoxin Almitrine Istaroxime Magnesium acetate Potassium acetate Potassium sulfate Potassium Magnesium levulinate Magnesium lactate Aluminium phosphate Aluminum acetate	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Coffee consumption ( 29367735) Macular thickness ( 30535121)	Type 2 diabetes ( 25760438)
Interacting Genes		18 interacting genes: A2M ADD1 CFL1 EGFR EZH2 FXYD1 FXYD2 FXYD7 GPR35 HGS MAPK1 MAPK3 NDRG1 PRKCA SNAPIN TPT1 ZNRF1 ZNRF2	30 interacting genes: APP ATP1A1 ATP1A2 BCL2L1 CALM1 DBN1 EEF1A1 EEF1A2 EEF1B2 EEF1D FANCA HSPB1 IKBKG LIG4 MCL1 MCPH1 MDM2 MLC1 NKX3-1 NOTCH3 PER2 PLK1 RBBP6 RPLP1 SNX6 SPP1 STEAP3 TRIP13 TUBB2A VHL
Entrez ID		476	7178
HPRD ID		01662	15979
Ensembl ID		ENSG00000163399	ENSG00000133112
Uniprot IDs		P05023	A0A024RDY2 A0A0B4J2C3 A0A0P1J1R0 P13693
PDB IDs			1YZ1 2HR9 3EBM 4Z9V 5O9L 5O9M 6IZB 6IZE
Enriched GO Terms of Interacting Partners?
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