CUL2 and MKNK2

Data Source:
BioGRID (two hybrid)

		CUL2	MKNK2
Description		cullin 2	MAPK interacting serine/threonine kinase 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Intrinsic Apoptotic Signaling Pathway	Regulation Of Translation Protein Phosphorylation Cell Surface Receptor Signaling Pathway Peptidyl-serine Phosphorylation Hemopoiesis Intracellular Signal Transduction Protein Autophosphorylation Cellular Response To Arsenic-containing Substance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Fostamatinib
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Nonsyndromic cleft lip with or without cleft palate ( 28087736)
Interacting Genes		25 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC GPS1 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 VHL ZER1 ZYG11B	13 interacting genes: CUL2 EIF4E EIF4G1 ESR1 ESR2 MAPK1 MAPK14 MAPK8 MESD PSMA1 RBX1 RPL7A VBP1
Entrez ID		8453	2872
HPRD ID		06786	05459
Ensembl ID		ENSG00000108094	ENSG00000099875
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617	B3KS07 Q9HBH9
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N	2AC3 2AC5 2HW7 6CJ5 6CJE 6CJH 6CJW 6CJY 6CK3 6CK6 6CKI 6JLR
Enriched GO Terms of Interacting Partners?
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