MKNK2 and CUL2

Data Source:
BioGRID (two hybrid)

		MKNK2	CUL2
Description		MAPK interacting serine/threonine kinase 2	cullin 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Translation Protein Phosphorylation Cell Surface Receptor Signaling Pathway Peptidyl-serine Phosphorylation Hemopoiesis Intracellular Signal Transduction Protein Autophosphorylation Cellular Response To Arsenic-containing Substance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	G1/S Transition Of Mitotic Cell Cycle Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Intrinsic Apoptotic Signaling Pathway
Pathways			Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		Nonsyndromic cleft lip with or without cleft palate ( 28087736)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		13 interacting genes: CUL2 EIF4E EIF4G1 ESR1 ESR2 MAPK1 MAPK14 MAPK8 MESD PSMA1 RBX1 RPL7A VBP1	25 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC GPS1 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 VHL ZER1 ZYG11B
Entrez ID		2872	8453
HPRD ID		05459	06786
Ensembl ID		ENSG00000099875	ENSG00000108094
Uniprot IDs		B3KS07 Q9HBH9	A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617
PDB IDs		2AC3 2AC5 2HW7 6CJ5 6CJE 6CJH 6CJW 6CJY 6CK3 6CK6 6CKI 6JLR	4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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