BRSK1 and CDC25B

Data Source:
HPRD (in vitro)

		BRSK1	CDC25B
Description		BR serine/threonine kinase 1	cell division cycle 25B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Synaptic Vesicle Cell Junction Presynaptic Active Zone Distal Axon	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Kinase Binding Gamma-tubulin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Neurotransmitter Secretion Axonogenesis Associative Learning Response To UV Response To Ionizing Radiation Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Neuron Differentiation Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Synaptic Plasticity Regulation Of Axonogenesis Centrosome Duplication Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Clustering	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Protein Phosphorylation Female Meiosis I Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cytokinesis Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Pathways			Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs			L-cysteic acid
Diseases
GWAS		Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 26414677)	Basophil percentage of granulocytes ( 27863252) Cognitive decline rate in late mild cognitive impairment ( 26252872) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		8 interacting genes: BRCA1 CDC25B CDC25C HSD17B7 HSPA1A MAPT PAK1 WEE1	28 interacting genes: AATK AR AURKA BRSK1 BRSK2 CDC14A CDK1 CDK2 CDK5 CHEK1 CREBBP CSNK2A1 CSNK2B ESR1 FHL3 KAT2B MAPK14 MAPK9 MAPKAPK2 MELK PGR PSME3 SFN YWHAB YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		84446	994
HPRD ID		12533	00307
Ensembl ID		ENSG00000160469	ENSG00000101224
Uniprot IDs		Q8TDC3	B3KS38 B4DIG0 B4DQZ3 B4DRC3 E1YMX4 G8JLH2 P30305 Q6MZW8
PDB IDs			1CWR 1CWS 1CWT 1QB0 1YM9 1YMD 1YMK 1YML 1YS0 2A2K 2IFD 2IFV 2UZQ 3FQT 3FQU 4WH7 4WH9
Enriched GO Terms of Interacting Partners?
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