RECK and SPSB2

Data Source:
BioGRID (two hybrid)

		RECK	SPSB2
Description		reversion inducing cysteine rich protein with kazal motifs	splA/ryanodine receptor domain and SOCS box containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane Wnt Signalosome	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Wnt-protein Binding Coreceptor Activity Involved In Canonical Wnt Signaling Pathway	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity	Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)	Colorectal cancer ( 26965516) Refractive error ( 32231278)
Interacting Genes		42 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704	12 interacting genes: APP DDX4 FNDC3B GALNT15 NOS2 NRF1 PAWR PRMT1 RECK SMARCD1 TRIM55 TRIM63
Entrez ID		8434	84727
HPRD ID		05567	13610
Ensembl ID		ENSG00000122707	ENSG00000111671
Uniprot IDs		A8K9D8 O95980 Q6P9E2	Q99619
PDB IDs			3EMW 5XN3 6DN5 6DN6 6JKJ 6JWM 6JWN 6KEY
Enriched GO Terms of Interacting Partners?
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