DNAJC30 and EXOSC6

Data Source:
HPRD (two hybrid)

		DNAJC30	EXOSC6
Description		DnaJ heat shock protein family (Hsp40) member C30	exosome component 6
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GO Annotations	Cellular Component	Mitochondrial Inner Membrane Integral Component Of Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol
	Molecular Function	Protein Binding	RNA Binding Exoribonuclease Activity
	Biological Process	ATP Biosynthetic Process Brain Development Regulation Of Mitochondrial ATP Synthesis Coupled Proton Transport	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Malaria ( 31844061)	Brain morphology (MOSTest) ( 32665545) Malaria ( 31844061)
Interacting Genes		31 interacting genes: APP AQP6 BEST2 CALN1 CREB3 EBP EXOSC6 FAM209A FATE1 FBXO7 GPX8 JAGN1 KASH5 LMNA LRRC25 MFSD14B MGST2 MRM1 MSMO1 OPRL1 PEX12 REEP4 RNF170 S100B SIGLEC12 SLC10A4 SLC35C2 SLC51A TMEM31 TMEM52B TMEM86B	37 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 HBS1L LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPHOSPH6 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PALS2 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		84277	118460
HPRD ID		10303	12107
Ensembl ID		ENSG00000176410	ENSG00000223496
Uniprot IDs		B3KSU4 Q96LL9	Q5RKV6
PDB IDs		2YUA	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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