SETD3 and MYOD1

Data Source:
BioGRID (pull down)

		SETD3	MYOD1
Description		SET domain containing 3, actin histidine methyltransferase	myogenic differentiation 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Myofibril
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Transcription Coactivator Activity Actin Binding Protein Binding Protein-lysine N-methyltransferase Activity Protein-histidine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K4 Specific) Histone Methyltransferase Activity (H3-K36 Specific)	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Histone H3-K36 Methylation Peptidyl-histidine Methylation Peptidyl-lysine Trimethylation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Actin Modification Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Muscle Cell Differentiation Histone H3-K4 Methylation Regulation Of Uterine Smooth Muscle Contraction	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Muscle Organ Development Myoblast Fate Determination Skeletal Muscle Tissue Development Myoblast Fusion Cellular Response To Starvation Myotube Cell Development Myotube Differentiation Involved In Skeletal Muscle Regeneration Negative Regulation Of Chromatin Binding Skeletal Muscle Cell Differentiation Muscle Cell Fate Commitment Positive Regulation Of Skeletal Muscle Tissue Regeneration Regulation Of RNA Splicing Skeletal Muscle Fiber Adaptation Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Binding Positive Regulation Of Muscle Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Positive Regulation Of Myoblast Fusion Positive Regulation Of SnRNA Transcription By RNA Polymerase II Negative Regulation Of Myoblast Proliferation
Pathways		PKMTs methylate histone lysines	Myogenesis Myogenesis
Drugs
Diseases
GWAS		Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Body mass index ( 26426971) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		4 interacting genes: APLNR APP MYOD1 SRPK1	67 interacting genes: AP1M1 ASCL3 BHLHA15 BHLHE40 BHLHE41 C2orf88 CALM1 CALM2 CALM3 CARM1 CDC34 CDK2 CDK4 CDKN1C CIB2 CREBBP CSRP3 ELSPBP1 EP300 EXOC3L1 FBXO32 FIGLA HAND1 HDAC1 HEY1 HSP90AA1 ID1 ID2 ID3 ID4 IFRD1 IGFN1 JUN KAT2B KAT5 KPNA3 LMO4 MDFI MEF2A MEF2C MOS MYOCD NCOR1 NCOR2 NR2F2 PHB2 POLR2G PRKCA PRMT5 PSMD4 PSME2 RB1 RORA RUNX1 RXRA SETD3 SMAD3 SMAD4 SMAD7 SP1 SRF STAT3 SUV39H1 TCF21 TCF3 TCF4 TWIST1
Entrez ID		84193	4654
HPRD ID		08664	01166
Ensembl ID		ENSG00000183576	ENSG00000129152
Uniprot IDs		A0A024R6K3 Q86TU7	P15172
PDB IDs		3SMT 6ICT 6ICV 6JAT 6MBJ 6MBK 6MBL 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5 6V62 6V63 6WK1 6WK2
Enriched GO Terms of Interacting Partners?
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