MYOD1 and PSMD4

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MYOD1	PSMD4
Description		myogenic differentiation 1	proteasome 26S subunit, non-ATPase 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Myofibril	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Muscle Organ Development Myoblast Fate Determination Skeletal Muscle Tissue Development Myoblast Fusion Cellular Response To Starvation Myotube Cell Development Myotube Differentiation Involved In Skeletal Muscle Regeneration Negative Regulation Of Chromatin Binding Skeletal Muscle Cell Differentiation Muscle Cell Fate Commitment Positive Regulation Of Skeletal Muscle Tissue Regeneration Regulation Of RNA Splicing Skeletal Muscle Fiber Adaptation Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Binding Positive Regulation Of Muscle Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Positive Regulation Of Myoblast Fusion Positive Regulation Of SnRNA Transcription By RNA Polymerase II Negative Regulation Of Myoblast Proliferation	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasome Assembly Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Myogenesis Myogenesis	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)	Body mass index ( 26426971)
Interacting Genes		67 interacting genes: AP1M1 ASCL3 BHLHA15 BHLHE40 BHLHE41 C2orf88 CALM1 CALM2 CALM3 CARM1 CDC34 CDK2 CDK4 CDKN1C CIB2 CREBBP CSRP3 ELSPBP1 EP300 EXOC3L1 FBXO32 FIGLA HAND1 HDAC1 HEY1 HSP90AA1 ID1 ID2 ID3 ID4 IFRD1 IGFN1 JUN KAT2B KAT5 KPNA3 LMO4 MDFI MEF2A MEF2C MOS MYOCD NCOR1 NCOR2 NR2F2 PHB2 POLR2G PRKCA PRMT5 PSMD4 PSME2 RB1 RORA RUNX1 RXRA SETD3 SMAD3 SMAD4 SMAD7 SP1 SRF STAT3 SUV39H1 TCF21 TCF3 TCF4 TWIST1	45 interacting genes: ADRM1 APP BTRC CCNA2 CUL1 EGFR FBXO25 FLOT1 GNB5 H2AC4 H2BC3 ID1 MAP3K1 MDM2 MYOD1 NEDD4 NEDD4L NEDD8 NUB1 PRKN PSMC3 PSMD7 PTEN RAD23A RAD23B RASSF8 RBCK1 SCHIP1 SIAH2 SMURF1 SREBF2 STUB1 TCF3 TCP11L1 TMEM129 TP53 TRIM63 UBB UBC UBD UBE2C UBQLN1 UBQLN2 USP7 XPC
Entrez ID		4654	5710
HPRD ID		01166	03386
Ensembl ID		ENSG00000129152	ENSG00000159352
Uniprot IDs		P15172	P55036 Q5VWC4
PDB IDs			1P9C 1P9D 1UEL 1YX4 1YX5 1YX6 2KDE 2KDF 5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6MUN 6U19 6WJD 6WJN
Enriched GO Terms of Interacting Partners?
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