SPOP and SRRM1

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology, two hybrid)

		SPOP	SRRM1
Description		speckle type BTB/POZ protein	serine and arginine repetitive matrix 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytosol Nuclear Matrix Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	DNA Binding RNA Binding Protein Binding
	Biological Process	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing
Pathways		Hedgehog 'on' state	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Male-pattern baldness ( 28196072) Systolic blood pressure ( 29208002)
Interacting Genes		66 interacting genes: AEN AMOTL2 AR BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I UBE2L3 VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	13 interacting genes: ABI1 CLK1 CLK2 CSNK2A1 DEK FUS PIN1 SPOP SRPK1 SRPK2 SRRM2 SRRM4 YWHAG
Entrez ID		8405	10250
HPRD ID		16004	10441
Ensembl ID		ENSG00000121067	ENSG00000133226
Uniprot IDs		O43791	A0A0S2Z4W1 B7Z7U0 Q8IYB3
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A	1MP1 6FF4 6FF7
Enriched GO Terms of Interacting Partners?
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