CTTNBP2 and KRT14

Data Source:
BioGRID (two hybrid)

		CTTNBP2	KRT14
Description		cortactin binding protein 2	keratin 14
Image		No pdb structure
GO Annotations	Cellular Component	Cell Cortex Synaptic Vesicle Dendritic Spine Postsynaptic Actin Cytoskeleton Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Basal Part Of Cell Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding SH3 Domain Binding	Structural Constituent Of Cytoskeleton Protein Binding Keratin Filament Binding
	Biological Process	Brain Development Regulation Of Modification Of Postsynaptic Actin Cytoskeleton	Aging Epidermis Development Response To Zinc Ion Response To Ionizing Radiation Keratinization Hemidesmosome Assembly Hair Cycle Intermediate Filament Bundle Assembly Cornification
Pathways			Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases			Naegeli-Franceschetti-Jadassohn syndrome Dermatopathia pigmentosa reticularis Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Brain morphology (MOSTest) ( 32665545) General factor of neuroticism ( 30867560) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 29891935) Idiopathic osteonecrosis of the femoral head ( 28000841) Intraocular pressure ( 29617998 29785010 31959993 30054594) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 30108155) Type 2 diabetes ( 30054458 30297969) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: APPL1 ARNTL2 CTTN FAM86C1P HSF2BP INCA1 KRT14 MAGEA11 MEI4 PKNOX2	32 interacting genes: ABI2 ABI3 AMOT APC BFSP2 CTTNBP2 DST ENKD1 GAS8 HGS HSPA5 KIFC3 KRT1 KRT3 KRT5 KRT6C KRT72 KRT78 KRT79 KRT80 KRT81 KRT86 OIP5 PKP1 PRPH PUS10 SDCBP SMARCE1 TCHP TRADD UBASH3A USHBP1
Entrez ID		83992	3861
HPRD ID		09890	01017
Ensembl ID		ENSG00000077063	ENSG00000186847
Uniprot IDs		Q20BG9 Q8WZ74	P02533
PDB IDs			3TNU 6JFV
Enriched GO Terms of Interacting Partners?
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