KRT14 and PKP1

Data Source:
HPRD (in vitro)

		KRT14	PKP1
Description		keratin 14	plakophilin 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Basal Part Of Cell Extracellular Exosome Cell Periphery	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Adherens Junction Desmosome Ficolin-1-rich Granule Membrane Messenger Ribonucleoprotein Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Keratin Filament Binding	Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Skin Epidermis Cadherin Binding
	Biological Process	Aging Epidermis Development Response To Zinc Ion Response To Ionizing Radiation Keratinization Hemidesmosome Assembly Hair Cycle Intermediate Filament Bundle Assembly Cornification	Cell-cell Junction Assembly Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Keratinization Neutrophil Degranulation Intermediate Filament Bundle Assembly Cornification Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs		Zinc Zinc acetate
Diseases		Naegeli-Franceschetti-Jadassohn syndrome Dermatopathia pigmentosa reticularis Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic	Ectodermal dysplasia/skin fragility syndrome
GWAS			Panic disorder ( 19165232) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		32 interacting genes: ABI2 ABI3 AMOT APC BFSP2 CTTNBP2 DST ENKD1 GAS8 HGS HSPA5 KIFC3 KRT1 KRT3 KRT5 KRT6C KRT72 KRT78 KRT79 KRT80 KRT81 KRT86 OIP5 PKP1 PRPH PUS10 SDCBP SMARCE1 TCHP TRADD UBASH3A USHBP1	16 interacting genes: BICDL2 CARD10 CEP76 DSC1 DSG1 DSP GOLGA2 GTF2IRD1 HOOK2 HSF2BP KRT14 KRT8 NFKBID TNS2 UCHL5 VIM
Entrez ID		3861	5317
HPRD ID		01017	03579
Ensembl ID		ENSG00000186847	ENSG00000081277
Uniprot IDs		P02533	A0A024R952 Q13835
PDB IDs		3TNU 6JFV	1XM9
Enriched GO Terms of Interacting Partners?
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