PIP5K1A and TEC

Data Source:
HPRD (in vivo, in vitro)

		PIP5K1A	TEC
Description		phosphatidylinositol-4-phosphate 5-kinase type 1 alpha	tec protein tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Nuclear Speck Lamellipodium Ruffle Membrane	Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Kinase Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Keratinocyte Differentiation Actin Cytoskeleton Reorganization Phosphatidylinositol Phosphorylation Focal Adhesion Assembly Cell Chemotaxis Protein Localization To Plasma Membrane Activation Of GTPase Activity Ruffle Assembly	Adaptive Immune Response Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Tissue Regeneration Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Synthesis of PIPs at the plasma membrane PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Body mass index ( 26426971)	Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30423114 24390342) Systolic blood pressure ( 27841878)
Interacting Genes		16 interacting genes: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 KRAS MIR140 MIR34B NEDD4 PIP5KL1 PLD1 PLD2 RHOU TEC	36 interacting genes: ARHGEF12 BMX BTK DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		8394	7006
HPRD ID		04470	02786
Ensembl ID		ENSG00000143398	ENSG00000135605
Uniprot IDs		A6PW57 Q99755	P42680
PDB IDs			2LUL
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?