FERMT3 and ANKRD29

Data Source:
BioGRID (two hybrid)

		FERMT3	ANKRD29
Description		FERM domain containing kindlin 3	ankyrin repeat domain 29
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Extracellular Region Membrane Cell-substrate Junction Platelet Alpha Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Integrin Binding	Protein Binding
	Biological Process	Platelet Degranulation Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Integrin Activation Regulation Of Cell-cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Platelet Aggregation
Pathways		Platelet degranulation
Drugs
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) Fruit consumption ( 32066663) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401)	Amyotrophic lateral sclerosis (sporadic) ( 24256812)
Interacting Genes		11 interacting genes: ANKRD29 APP EXOSC10 ILK ITGB1 LIMS1 LSM8 PARVA PRPF18 TINF2 TRIM15	10 interacting genes: CABP2 CRACR2A FAM90A1 FERMT3 GTF2H5 GYPA HLCS MRPL53 RABGEF1 USP32
Entrez ID		83706	147463
HPRD ID		07440	12464
Ensembl ID		ENSG00000149781	ENSG00000154065
Uniprot IDs		Q86UX7	Q8N6D5
PDB IDs		2YS3 6V97 6V9G 7C3M
Enriched GO Terms of Interacting Partners?
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