ANKRD29 and FERMT3

Data Source:
BioGRID (two hybrid)

		ANKRD29	FERMT3
Description		ankyrin repeat domain 29	FERM domain containing kindlin 3
Image		No pdb structure
GO Annotations	Cellular Component		Podosome Extracellular Region Membrane Cell-substrate Junction Platelet Alpha Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding	Integrin Binding
	Biological Process		Platelet Degranulation Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Integrin Activation Regulation Of Cell-cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Platelet Aggregation
Pathways			Platelet degranulation
Drugs
Diseases			Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24256812)	Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) Fruit consumption ( 32066663) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401)
Interacting Genes		10 interacting genes: CABP2 CRACR2A FAM90A1 FERMT3 GTF2H5 GYPA HLCS MRPL53 RABGEF1 USP32	11 interacting genes: ANKRD29 APP EXOSC10 ILK ITGB1 LIMS1 LSM8 PARVA PRPF18 TINF2 TRIM15
Entrez ID		147463	83706
HPRD ID		12464	07440
Ensembl ID		ENSG00000154065	ENSG00000149781
Uniprot IDs		Q8N6D5	Q86UX7
PDB IDs			2YS3 6V97 6V9G 7C3M
Enriched GO Terms of Interacting Partners?
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