PARP9 and DTX3L

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PARP9	DTX3L
Description		poly(ADP-ribose) polymerase family member 9	deltex E3 ubiquitin ligase 3L
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Protein-containing Complex Site Of DNA Damage	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Early Endosome Cytosol Early Endosome Membrane Protein-containing Complex
	Molecular Function	Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity Enzyme Inhibitor Activity Protein Binding Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding NAD+ Binding ADP-D-ribose Binding STAT Family Protein Binding Protein ADP-ribosylase Activity	Ubiquitin-protein Transferase Activity Enzyme Inhibitor Activity Protein Binding Enzyme Activator Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity STAT Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Defense Response To Virus By Host Double-strand Break Repair Protein ADP-ribosylation Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Chromatin Binding Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Transcription, DNA-templated Defense Response To Virus Regulation Of Response To Interferon-gamma Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Protein Poly-ADP-ribosylation Protein Mono-ADP-ribosylation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Protein Polyubiquitination Positive Regulation Of Defense Response To Virus By Host Double-strand Break Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Notch Signaling Pathway Endosome To Lysosome Transport Histone Monoubiquitination Protein Transport Viral Process Protein Ubiquitination Positive Regulation Of Protein Binding Histone H2A Ubiquitination Histone H2B Ubiquitination Positive Regulation Of Chromatin Binding Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Ubiquitin-protein Transferase Activity Defense Response To Virus Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Receptor Catabolic Process Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Nicotinamide salvaging Maturation of nucleoprotein Maturation of nucleoprotein	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		LDL cholesterol levels ( 32203549) Major depressive disorder ( 22472876) Parkinson's disease ( 32201043) Total cholesterol levels ( 30275531)	Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 22472876)
Interacting Genes		1 interacting genes: DTX3L	20 interacting genes: DTX1 H2AZ2 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W
Entrez ID		83666	151636
HPRD ID		10686	16843
Ensembl ID		ENSG00000138496	ENSG00000163840
Uniprot IDs		Q59ER9 Q8IXQ6	Q8TDB6
PDB IDs		5AIL	3PG6
Enriched GO Terms of Interacting Partners?
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